Temporal profile of serum neurofilament light in multiple sclerosis: Implications for patient monitoring

Monitoring disease activity in multiple sclerosis using serum neurofilament light protein

OBJECTIVE To examine the effects of disease activity, disability, and disease-modifying therapies (DMTs) on serum neurofilament light (NFL) and the correlation between NFL concentrations in serum and CSF in multiple sclerosis (MS). METHODS NFL concentrations were measured in paired serum and CSF samples (n = 521) from 373 participants: 286 had MS, 45 had other neurologic conditions, and 42 we...

Neurofilament light chain gene polymorphism and risk of multiple sclerosis in Iranian patients

Background: Multiple sclerosis (MS) is a chronic disease characterized by inflammation and degeneration of the central nervous system (CNS). High levels of Neurofilament light chain (NFL) and Neurofilament heavy chain (NFH) in cerebrospinal fluid (CSF) have been associated with a wide range of neurological diseases including MS. Subjects and methods: Peripheral blood samples were collected from...

Neurofilament light antibodies in serum reflect response to natalizumab treatment in multiple sclerosis.

BACKGROUND Increased levels of antibodies to neurofilament light protein (NF-L) in biological fluids have been found to reflect neuroinflammatory responses and neurodegeneration in multiple sclerosis (MS). OBJECTIVE To evaluate whether levels of serum antibodies against NF-L correlate with clinical variants and treatment response in MS. METHODS The autoantibody reactivity to NF-L protein wa...

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis

OBJECTIVE Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single-molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS). METHOD...

CSF neurofilament light: A universal risk biomarker in multiple sclerosis?